Due to its importance for the body, the brain is protected not only by the skull, but also by the blood-brain barrier, which prevents a large number of drugs from entering the brain tissue. This is good from the point of view of protecting the brain, but it presents significant difficulties for doctors if they want to apply therapy to treat a tumor located in the brain. According to new research by Song and colleagues, this barrier can be bypassed when its existence is counterproductive, which was achieved by modulating the immune system in an animal model. Through the ectopic expression of vascular endothelial growth factor C (VEGF-C), the migration of immune cells to the tumor area and a long-term antitumor response to glioblastoma are stimulated. Researchers hope that based on this mechanism, new ways of treating this aggressive disease will be established.
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